Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis

S Afr Med J. 1986 Jan 4;69(1):39-42.

Abstract

The value of cerebrospinal fluid (CSF) lactate and lactate dehydrogenase (LD) activity in the rapid diagnosis of meningitis was investigated in three groups of patients--a 'no meningitis', an aseptic meningitis and a bacterial meningitis group. The sensitivity achieved in the detection of bacterial meningitis by CSF lactate values of 2.85 mmol/l (93.8%) and 3.9 mmol/l (89.6%) was greater than that reached by conventional chemical investigations using a CSF protein value of 1 g/l (81.5%) or a CSF glucose value of 2.2 mmol/l (68.8%) as the indicator. The sensitivity of an absolute CSF LD value of 40 U/l (86.3%) in the detection of bacterial meningitis was slightly lower than that of a CSF protein value of 1 g/l (87%) and better than the sensitivity of either a CSF/serum LD ratio of 0.1:1.0 (83.9%) or a CSF glucose level of 2.2 mmol/l (76.3%). As with conventional CSF chemistry, both investigations may give normal values in the presence of bacterial meningitis.

Publication types

  • Comparative Study

MeSH terms

  • Child
  • Child, Preschool
  • Enterobacteriaceae Infections / cerebrospinal fluid
  • Enterobacteriaceae Infections / diagnosis
  • Humans
  • Infant
  • L-Lactate Dehydrogenase / cerebrospinal fluid*
  • Lactates / cerebrospinal fluid*
  • Meningitis / cerebrospinal fluid
  • Meningitis / diagnosis*
  • Meningitis, Aseptic / cerebrospinal fluid
  • Meningitis, Haemophilus / cerebrospinal fluid
  • Meningitis, Haemophilus / diagnosis
  • Meningitis, Meningococcal / cerebrospinal fluid
  • Meningitis, Meningococcal / diagnosis
  • Meningitis, Pneumococcal / cerebrospinal fluid
  • Meningitis, Pneumococcal / diagnosis
  • Tuberculosis, Meningeal / cerebrospinal fluid
  • Tuberculosis, Meningeal / diagnosis

Substances

  • Lactates
  • L-Lactate Dehydrogenase