Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer

Clin Cancer Res. 2025 Jan 6;31(1):10-11. doi: 10.1158/1078-0432.CCR-24-2738.

Abstract

Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment. See related article by Lanickova et al., p. 164.

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Female
  • Humans
  • Neoplasm Metastasis
  • Ovarian Neoplasms* / drug therapy
  • Ovarian Neoplasms* / immunology
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / therapy
  • Tertiary Lymphoid Structures* / immunology
  • Tertiary Lymphoid Structures* / pathology
  • Tumor Microenvironment* / drug effects
  • Tumor Microenvironment* / immunology

Substances

  • Antineoplastic Agents