The role of c-Myc in Epstein-Barr virus-associated cancers: Mechanistic insights and therapeutic implications

Microb Pathog. 2024 Dec:197:107025. doi: 10.1016/j.micpath.2024.107025. Epub 2024 Oct 18.

Abstract

c-Myc is an important proto-oncogene belonging to the MYC family. In normal conditions, c-Myc regulates different aspects of cellular function. However, its dysregulation can result in the development of cancer due to various mechanisms. Epstein-Barr virus is a ubiquitous viral pathogen that infects a huge proportion of the global population. This virus is linked to various cancers, such as different types of lymphoma, nasopharyngeal, and gastric cancers. It can manipulate host cells, and many cellular and viral genes are important in the Epstein-Barr virus carcinogenesis. This review explores the complex relationship between c-Myc and Epstein-Barr virus in the context of cancer development. Also, potential therapeutic strategies targeting c-Myc to treat EBV-related cancers are discussed.

Keywords: Epstein-barr virus; Gastric cancer; Lymphoma; Nasopharyngeal carcinoma; c-Myc.

Publication types

  • Review

MeSH terms

  • Carcinogenesis
  • Epstein-Barr Virus Infections* / complications
  • Epstein-Barr Virus Infections* / virology
  • Herpesvirus 4, Human* / genetics
  • Host-Pathogen Interactions
  • Humans
  • Lymphoma / virology
  • Neoplasms* / therapy
  • Neoplasms* / virology
  • Proto-Oncogene Mas*
  • Proto-Oncogene Proteins c-myc* / genetics
  • Proto-Oncogene Proteins c-myc* / metabolism
  • Stomach Neoplasms / virology

Substances

  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Mas
  • MAS1 protein, human
  • MYC protein, human