A male patient presented to the clinic with persistent hiccups and the complaint of subacute low back pain. Subsequently, he was administered a transforaminal epidural betamethasone injection (TFESI) plus lidocaine and developed persistent hiccups thereafter, which lasted for 6 days and subsided spontaneously. He presented with similar complaints again 5 months later and was administered TFESI, this time along with betamethasone and saline. Yet, he once again developed persistent hiccups, which this time lasted for 7 days and subsided spontaneously. This case report, featuring a patient who was administered TFESI due to subacute low back pain and subsequently developed persistent hiccups as a rare complication, aims to contribute to the literature in the relevant area of specialization.