A possible new type of chromosome rearrangement: telomere-centromere translocation (tct) followed by double duplication

Hum Genet. 1986 Jan;72(1):25-6. doi: 10.1007/BF00278812.


The reassessment of a case of complex interchromosomal rearrangement after breakage at centromeric and telomeric regions, and the comparison with four other independently published cases suggested the existence of a new type of rearrangement. It would consist of: formation of an isochromosome after breakage at a centromeric region, duplication of the telomeric region of another chromosome, and reassociation of the nonduplicated arm of the first chromosome with the duplicated telomeric region of the second chromosome.

MeSH terms

  • Centromere*
  • Chromosome Banding
  • Chromosomes*
  • Chromosomes, Human, 1-3
  • Chromosomes, Human, 4-5
  • Humans
  • Karyotyping
  • Translocation, Genetic*