Association between air pollution and bone mineral density: a Mendelian randomization study

Rui Jiang; Qi Qu; Zhiyu Wang; Feng Luo; Shuanglin Mou

doi:10.5114/aoms/192628

Association between air pollution and bone mineral density: a Mendelian randomization study

Arch Med Sci. 2024 Aug 28;20(4):1334-1338. doi: 10.5114/aoms/192628. eCollection 2024.

Authors

Rui Jiang^{1

2}, Qi Qu^{2

3}, Zhiyu Wang^{2

3}, Feng Luo⁴, Shuanglin Mou²

Affiliations

¹ Graduate School, Hubei University of Traditional Chinese Medicine, Wuhan, China.
² Department of Orthopedics, Huanggang Hospital of Traditional Chinese Medicine, Huanggang, China.
³ Medical College, Hubei Minzu University, Enshi, China.
⁴ Department of Rehabilitation, Huanggang Central Hospital, Huanggang, China.

Abstract

Introduction: The association of air pollution with bone mineral density (BMD) has attracted increasing attention. However, establishing a causal relationship remains uncertain.

Methods: We conducted a Mendelian randomization (MR) study employing PM_2.5, PM_2.5-10, PM₁₀, nitrogen dioxide, and nitrogen oxides as exposures and BMD as the outcome to explore the causality between air pollution and the occurrence of decreased BMD.

Results: By employing the IVW method, we identified a negative causality between air pollution (PM_2.5, PM₁₀, and nitrogen oxides) and BMD.

Conclusions: Our findings demonstrate that PM_2.5, PM₁₀ and nitrogen oxides exposure may contribute to decreased BMD.

Keywords: Mendelian randomization; air pollution; bone mineral density; causal relationship; osteoporosis.