Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia

Emerg Infect Dis. 2024 Nov;30(11):2429-2432. doi: 10.3201/eid3011.231393.

Abstract

In Slovenia, primary acellular pertussis vaccines (ACVs) containing pertactin (PRN) were mostly used during 1999-2016; ACVs without PRN were introduced in 2017. Among 123 Bordetella pertussis strains collected during 2002-2020, a total of 48 were PRN-deficient; 44 were collected after 2017. Changes to ACVs could increase PRN-deficient B. pertussis and infections.

Keywords: Bordetella pertussis; Slovenia; acellular pertussis vaccine; bacteria; pertactin; respiratory infections.

MeSH terms

  • Bacterial Outer Membrane Proteins* / genetics
  • Bordetella pertussis* / genetics
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Pertussis Vaccine* / administration & dosage
  • Pertussis Vaccine* / immunology
  • Prevalence
  • Slovenia / epidemiology
  • Virulence Factors, Bordetella* / genetics
  • Whooping Cough* / epidemiology
  • Whooping Cough* / microbiology
  • Whooping Cough* / prevention & control

Substances

  • pertactin
  • Virulence Factors, Bordetella
  • Bacterial Outer Membrane Proteins
  • Pertussis Vaccine