Proliferating bipotential glial progenitor cells in adult rat optic nerve

Nature. 1986 Feb 6-12;319(6053):499-502. doi: 10.1038/319499a0.

Abstract

We have shown previously that the rat optic nerve contains three types of macroglial cells--oligodendrocytes and two types of astrocytes--which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16), while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively. Here we report that proliferating bipotential oligodendrocyte-type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / physiology
  • Cell Division / drug effects
  • Cells, Cultured
  • DNA Replication / drug effects
  • Neuroglia / cytology
  • Neuroglia / physiology*
  • Optic Nerve / cytology
  • Optic Nerve / physiology*
  • Polylysine / pharmacology
  • Rats
  • Rats, Inbred Strains

Substances

  • Polylysine