Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus

Virology. 1986 Mar;149(2):251-4. doi: 10.1016/0042-6822(86)90127-3.

Abstract

The 3' RNA base sequences of several Marburg (MBG) and Ebola (EBO) virus isolates have been determined. A comparison of these 3' terminal noncoding sequences with those of other negative strand RNA viruses suggests a unique phylogenic niche for Marburg and Ebola viruses. The translation initiation site and 35 N-terminal amino acids of the 3' proximal coding gene of a Zaire strain of Ebola virus was predicted. In addition, putative leader RNA sequences preceding the first gene are discussed in terms of possible regulatory functions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Capsid / genetics
  • Codon
  • Ebolavirus / classification
  • Ebolavirus / genetics
  • Genes, Viral
  • Marburgvirus / classification
  • Marburgvirus / genetics*
  • Protein Biosynthesis
  • RNA, Viral / genetics*
  • Rhabdoviridae / genetics*
  • Sequence Homology, Nucleic Acid
  • Viral Core Proteins / genetics

Substances

  • Codon
  • RNA, Viral
  • Viral Core Proteins