DENV and ZIKV infection: Species specificity and broad cell tropism

Zhen Wu; Yu He; Tao Wang; Mingshu Wang; Anchun Cheng; Shun Chen

doi:10.1016/j.virol.2024.110276

DENV and ZIKV infection: Species specificity and broad cell tropism

Virology. 2024 Dec:600:110276. doi: 10.1016/j.virol.2024.110276. Epub 2024 Oct 23.

Authors

Zhen Wu¹, Yu He¹, Tao Wang², Mingshu Wang², Anchun Cheng³, Shun Chen⁴

Affiliations

¹ Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Agricultural Bioinformatics of Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
² Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
³ Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Electronic address: chenganchun@vip.163.com.
⁴ Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Agricultural Bioinformatics of Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Electronic address: shunchen@sicau.edu.cn.

PMID: 39467358
DOI: 10.1016/j.virol.2024.110276

Abstract

Nearly one-third of countries worldwide have reported cases of Dengue virus (DENV) and Zika virus (ZIKV) infections, highlighting the significant threat these viruses pose to global public health. As members of the Flavivirus genus within the Flaviviridae family, DENV and ZIKV have demonstrated the ability to infect a wide range of cell lines from multiple species in vitro. However, the range of susceptible animal models is notably limited, and field studies indicate that their capacity to infect host organisms is highly restricted, with a very narrow range of target cells in vivo. The virus's ability to hijack host cellular machinery plays a crucial role in determining its cellular and species specificity. In this review, we examine how DENV and ZIKV exploit host cells to facilitate their replication, offering new insights that could inform the development of antiviral drugs and therapeutic targets.

Keywords: Flavivirus; Innate immune; Species specificity; Tropism.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dengue Virus* / genetics
Dengue Virus* / physiology
Dengue* / virology
Host Specificity
Host-Pathogen Interactions
Humans
Species Specificity
Viral Tropism*
Virus Replication*
Zika Virus Infection* / virology
Zika Virus* / genetics
Zika Virus* / physiology