Injecting drug use is a risk factor for methicillin resistance in patients with Staphylococcus aureus bloodstream infections

Intern Med J. 2024 Nov;54(11):1903-1908. doi: 10.1111/imj.16529. Epub 2024 Oct 29.

Abstract

We investigated whether injecting drug use was a risk factor for methicillin resistance among inpatients with Staphylococcus aureus bloodstream infections (SABSIs) at an Australian health service. In 273 inpatients, 46 (16.9%) of SABSIs were methicillin-resistant S. aureus (MRSA). MRSA was more frequent in those who had injected drugs in the past 6 months (20.6%) compared with other inpatients (15.7%). Injecting drug use was associated with a 4.82-fold (95% confidence interval = 1.54-16.29) increased odds of MRSA after accounting for confounders.

Keywords: Staphylococcus aureus; bloodstream infection; drug resistance; hospitalisation; substance‐related disorders.

MeSH terms

  • Adult
  • Aged
  • Australia / epidemiology
  • Bacteremia* / drug therapy
  • Bacteremia* / epidemiology
  • Bacteremia* / microbiology
  • Female
  • Humans
  • Male
  • Methicillin Resistance
  • Methicillin-Resistant Staphylococcus aureus* / drug effects
  • Middle Aged
  • Risk Factors
  • Staphylococcal Infections* / drug therapy
  • Staphylococcal Infections* / epidemiology
  • Substance Abuse, Intravenous* / complications
  • Substance Abuse, Intravenous* / epidemiology