Pharmacologic treatment of parkinsonian tremor

Arch Neurol. 1986 Feb;43(2):126-7. doi: 10.1001/archneur.1986.00520020020009.


The relative efficacy of trihexiphenidyl hydrochloride, amantadine hydrochloride, and low-dose carbidopa-levodopa in reducing parkinsonian tremor was investigated using objective techniques. Trihexiphenidyl and carbidopa-levodopa decreased tremor by greater than 50%. Some patients responded to one drug but not to the other. Amantadine decreased tremor less than 25%. Monotherapy with trihexiphenidyl or carbidopa-levodopa should be the initial treatment for the tremor of Parkinson's disease.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amantadine / therapeutic use*
  • Carbidopa / therapeutic use*
  • Drug Combinations / therapeutic use
  • Humans
  • Levodopa / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Tremor / drug therapy
  • Trihexyphenidyl / therapeutic use*


  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Trihexyphenidyl
  • Amantadine
  • Carbidopa