Preparation of a short synthetic apurinic oligonucleotide

Biochem Biophys Res Commun. 1986 Feb 13;134(3):1204-8. doi: 10.1016/0006-291x(86)90378-5.

Abstract

The synthesis of the model apurinic oligonucleotide Tp(AP)pT is reported. Furthermore during the course of purification of this compound we have shown that the adduct formed upon reaction with methoxyamine has a Schiff base structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apurinic Acid / chemical synthesis*
  • Chromatography, High Pressure Liquid
  • Hydroxylamines / analysis
  • Magnetic Resonance Spectroscopy*
  • Mass Spectrometry
  • Oligodeoxyribonucleotides / chemical synthesis*
  • Polynucleotides / chemical synthesis*
  • Schiff Bases

Substances

  • Hydroxylamines
  • Oligodeoxyribonucleotides
  • Polynucleotides
  • Schiff Bases
  • Apurinic Acid
  • methoxyamine