The Long-Term Health Outcomes of People Living with Perinatal Human Immunodeficiency Virus: A Scoping Review

Abstract

Since the first reported cases of perinatally acquired human immunodeficiency virus (HIV) in 1982, a generation born with HIV has reached adulthood. The authors conducted a scoping review of PubMed and Google Scholar for articles published between January 2000 and June 2023 to assess the long-term, multisystem health outcomes of this population. Long-term health outcomes studied in this population pertain to the effects of perinatal HIV (PHIV) infection and life-long antiretroviral therapy on the endocrine, reproductive, psychosocial, neurobehavioral, immunologic, and cardiovascular systems. Holistic health of all body systems should be considered in the long-term care of people with PHIV.

Keywords: Antiretroviral treatment resistance; Growth and development; HIV; Immunologic outcomes; Long-term health outcomes; Perinatal HIV; Psychosocial and behavioral health; Reproductive health.