ANGPTL3 as a target for treating lipid disorders in type 2 diabetes patients

Lipids Health Dis. 2024 Nov 1;23(1):356. doi: 10.1186/s12944-024-02352-1.

Abstract

Type 2 diabetes mellitus (T2DM) is a globally prevalent metabolic disorder, and cardiovascular disease (CVD) is a significant cause of mortality and morbidity in diabetic individuals. In addition to hyperglycemia, lipid abnormalities associated with T2DM play a crucial role in the development of CVD complications. Diabetic dyslipidemia is characterized by elevated levels of triglyceride (TG)-rich lipoproteins and small dense low-density lipoprotein (LDL) particles, reduced high-density lipoprotein (HDL) cholesterol, and impaired HDL function. Angiopoietin protein-like 3 (ANGPTL3) is a liver-derived protein that plays a crucial role in regulating plasma lipoprotein metabolism by inhibiting lipoprotein lipase and influencing lipid levels. Inhibiting ANGPTL3 has shown promising effects in promoting HDL-mediated cholesterol reverse transport and reducing the levels of TG-rich lipoproteins and LDL cholesterol. Here, we explore the potential of ANGPTL3 as a therapeutic target for lipid management in T2DM patients.

Keywords: Angiopoietin-like protein 3; Cardiovascular disease; Diabetic dyslipidemia; Insulin resistance; Type 2 diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Angiopoietin-Like Protein 3*
  • Angiopoietin-like Proteins* / antagonists & inhibitors
  • Cardiovascular Diseases
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Diabetes Mellitus, Type 2* / blood
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / drug therapy
  • Diabetes Mellitus, Type 2* / metabolism
  • Dyslipidemias / blood
  • Dyslipidemias / drug therapy
  • Humans
  • Lipid Metabolism / drug effects
  • Lipoprotein Lipase / metabolism
  • Lipoproteins / blood
  • Lipoproteins / metabolism
  • Triglycerides* / blood

Substances

  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins
  • ANGPTL3 protein, human
  • Triglycerides
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Lipoprotein Lipase
  • Lipoproteins