The generation of dense granules within cultured human retinal pigment epithelial cells at senescence

Graefes Arch Clin Exp Ophthalmol. 1986;224(2):106-9. doi: 10.1007/BF02141479.


Human retinal pigment epithelial cells routinely lose all forms of pigmentary inclusion when cultured. We report the repigmentation of a senescent population of cells. The pigmented inclusions were found to be neither melanin or lipofuscin but some form of dense membranous lamellae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival
  • Cells, Cultured
  • Child, Preschool
  • Cytoplasmic Granules / ultrastructure*
  • Humans
  • Laurence-Moon Syndrome / pathology
  • Microscopy, Electron
  • Pigment Epithelium of Eye / pathology
  • Pigment Epithelium of Eye / ultrastructure*