Association of Stress Hyperglycemia Ratio and in-Hospital Mortality in Patients with Sepsis: A Two Center Retrospective Cohort Study

Chaoping Ma; Weisong Jiang; Juan Li; Wenwu Sun; Jiyuan Zhang; Peixian Xu; Yiran Guo; Ning Ning; Jiaoyan Li; Bing Zhao; Enqiang Mao; Chengjin Gao

doi:10.2147/JIR.S476898

Association of Stress Hyperglycemia Ratio and in-Hospital Mortality in Patients with Sepsis: A Two Center Retrospective Cohort Study

J Inflamm Res. 2024 Oct 30:17:7939-7950. doi: 10.2147/JIR.S476898. eCollection 2024.

Authors

Chaoping Ma^#¹, Weisong Jiang^#², Juan Li^#¹, Wenwu Sun^#², Jiyuan Zhang¹, Peixian Xu¹, Yiran Guo¹, Ning Ning², Jiaoyan Li², Bing Zhao², Enqiang Mao², Chengjin Gao¹

Affiliations

¹ Departments of Emergency, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, People's Republic of China.
² Departments of Emergency, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic of China.

^# Contributed equally.

Abstract

Introduction: In critically ill patients, the stress hyperglycemia ratio (SHR) was significantly associated with mortality. However, the relationship between SHR and mortality in septic patients is still unclear.In this study, patients with sepsis from two Chinese academic centers were identified and divided into quartiles based on SHR levels.

Methods: Multivariable regression analysis will be used to determine associations between SHR and clinical outcomes in sepsis patients.The Kaplan-Meier curve was used to predict mortality in various groups of septic patients.

Results: A total of 1835 septic patients were included in the study.The in-hospital, 30-day, and 60-day mortality rates for all septic patients were 22.8%, 18.7%, and 21.7%, respectively. Increased SHR was significantly associated with hospital mortality in multivariate regression analysis.These results were further confirmed in the adjusted analysis, where the hospital mortality and the 60-day mortality of the highest SHR quartile were significantly increased compared to the lowest SHR quartile. However, the highest SHR quartile was not associated with 30-day mortality.In addition, the risk of in-hospital mortality, 30-day mortality and 60-day mortality showed a consistent upward trend with increasing SHR quartile. The survival curve showed that the worst prognosis was in the fourth SHR quartile.

Discussion: In conclusion, SHR was significantly associated with hospital mortality in patients with sepsis. This finding indicates that the SHR may be useful in identifying septic patients at higher risk of hospital mortality.

Keywords: Hyperglycemia; mortality; sepsis; stress hyperglycemia ratio.

Grants and funding

This work was supported by Key Supporting Subject Researching Project of Shanghai Municipal Health Commission (No. 2023ZDFC0106);the Science and Technology of Shanghai Committee (23Y31900100, 23Y31900102 and 21MC1930400);National Natural Science Foundation of China (No. 82172138);Innovation Research Project of Shanghai Science and Technology Commission (No. 21Y11902400).