In symptomatic knee OA, adding oral methotrexate to usual analgesia reduced pain at 6 mo

Ann Intern Med. 2024 Nov;177(11):JC130. doi: 10.7326/ANNALS-24-02769-JC. Epub 2024 Nov 5.

Abstract

Kingsbury SR, Tharmanathan P, Keding A, et al. Pain reduction with oral methotrexate in knee osteoarthritis: a randomized, placebo-controlled clinical trial. Ann Intern Med. 2024;177:1145-1156. 39074374.