Amine N-methyltransferases from rabbit liver

J Biol Chem. 1986 Mar 25;261(9):3996-4001.


N-Methylation of amines has been ascribed to enzymes listed as amine N-methyltransferase, indolethylamine N-methyltransferase, and arylamine N-methyltransferase. All of these activities are accomplished by each of two related enzymes present in rabbit liver. The two N-methyltransferases have a very broad and overlapping specificity for primary and secondary amines. Both have a molecular mass of 30,000 daltons and react with an antibody formed to one of them, but have different isoelectric points.

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Chromatography, High Pressure Liquid
  • Isoelectric Point
  • Isoenzymes / metabolism
  • Kinetics
  • Liver / enzymology*
  • Methyltransferases / isolation & purification*
  • Molecular Weight
  • Rabbits
  • Tryptamines / metabolism


  • Amino Acids
  • Isoenzymes
  • Tryptamines
  • tryptamine
  • Methyltransferases
  • tryptamine N-methyltransferase