Gender variations in 30-day outcomes following cholecystectomy in patients with biliary acute pancreatitis

Abstract

Background: Biliary acute pancreatitis (BAP) can be associated with severe morbidity and mortality. This study aims to evaluate whether gender is associated with worse 30-day postoperative outcomes following cholecystectomy for BAP.

Methods: Patients in the ACS-NSQIP database (2014-2017) with a diagnosis of BAP who underwent cholecystectomy were stratified into two groups: male and female. Patients' demographic characteristics, perioperative data, and 30- day outcomes between the two groups were compared using univariate and multivariable analyses.

Result: 4158 (1556 male, 2602 female) patients were examined. Male gender was found to have significantly higher rates of both serious and overall morbidity. On multivariable analysis, male gender was an independent predictor of serious morbidity. No difference in mortality between the two groups was noted.

Conclusion: Male gender is associated with an increased rate of morbidity after cholecystectomy in patients with BAP, however there is no difference in mortality between the male and female genders.

Keywords: Acute pancreatitis; Biliary pancreatitis; Gallstone pancreatitis.