Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?

Curr Osteoporos Rep. 2024 Nov 1;23(1):1. doi: 10.1007/s11914-024-00895-x.

Abstract

Purpose of review: Sarcopenia, generally characterized by the age-related reduction in muscle strength, lean/muscle mass and functional ability, is also associated with reduced bone mass and strength and impaired brain health and function. One potential intervention which has received much 'hype' over the past few decades to countermeasure these negative consequences of biological aging is creatine monohydrate supplementation.

Recent findings: From a skeletal muscle perspective, the combination of creatine monohydrate supplementation and resistance training provides 'hope' for older adults as it improves measures of lean mass, regional (limb) muscle thickness, upper- and lower-body muscle strength and functional ability. Further, there is some evidence that creatine (supplementation or habitual diet) provides a ray of 'hope' for improving some aspects of cognitive function. The majority of research suggests that creatine is more 'hype' than 'hope' for improving measures of bone mass in older adults. Creatine monohydrate supplementation provides some anti-sarcopenic benefits for older adults.

Keywords: Aging; Cognition; Functional ability; Sarcopenia; Strength.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / physiology
  • Bone Density* / drug effects
  • Brain* / drug effects
  • Cognition / drug effects
  • Creatine* / administration & dosage
  • Creatine* / therapeutic use
  • Dietary Supplements*
  • Humans
  • Muscle Strength* / drug effects
  • Muscle, Skeletal* / drug effects
  • Resistance Training*
  • Sarcopenia* / prevention & control

Substances

  • Creatine