Outer-surface adduct formation and selective separation of cis-type gallated and cis-type non-gallated catechins using cucurbit[7]uril

Hiroyuki Tsutsumi; An Miura; Asuka Hanada; Rino Sonoda; Rie Nakashima; Tomonori Ohata; Hirohito Ikeda

doi:10.1039/d4cc05035e

Outer-surface adduct formation and selective separation of cis-type gallated and cis-type non-gallated catechins using cucurbit[7]uril

Chem Commun (Camb). 2024 Nov 26;60(95):14093-14096. doi: 10.1039/d4cc05035e.

Authors

Hiroyuki Tsutsumi¹, An Miura¹, Asuka Hanada¹, Rino Sonoda¹, Rie Nakashima¹, Tomonori Ohata¹, Hirohito Ikeda¹

Affiliation

¹ Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. h-tsutsumi@fukuoka-u.ac.jp.

PMID: 39513762
DOI: 10.1039/d4cc05035e

Abstract

We found that cis-type gallated and non-gallated catechins form low water solubility outer-surface adducts with cucurbit[7]uril in aqueous solution, with cis-type gallated catechins showing a higher tendency to precipitate as outer-surface adducts. By exploiting this phenomenon, we achieved the selective separation of cis-type gallated and non-gallated catechins in solution.