Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar;36(3):357-61.
doi: 10.1212/wnl.36.3.357.

Adrenoleukodystrophy: Oleic Acid Lowers Fibroblast Saturated C22-26 Fatty Acids

Adrenoleukodystrophy: Oleic Acid Lowers Fibroblast Saturated C22-26 Fatty Acids

W B Rizzo et al. Neurology. .

Abstract

Monounsaturated fatty acids, especially oleic acid (C18:1), decreased the content of saturated very-long-chain fatty acids (VLFA) in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and controls. When confluent ALD fibroblasts were incubated with oleic acid for 5 days in lipid-free medium, which eliminates uptake of exogenous VLFA, the mean cell content of C26:0 was decreased by 33.7 +/- 10.1%. Oleic acid inhibited C26:0 synthesis in ALD fibroblasts by 58% and total fatty acid synthesis by 68 to 78%. Therefore, the elevated C26:0 levels in ALD cells may be lowered by inhibiting fatty acid biosynthesis, and inhibition of saturated VLFA synthesis by oleate may be useful in treating ALD.

Similar articles

See all similar articles

Cited by 24 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback