Adrenoleukodystrophy: oleic acid lowers fibroblast saturated C22-26 fatty acids

Neurology. 1986 Mar;36(3):357-61. doi: 10.1212/wnl.36.3.357.


Monounsaturated fatty acids, especially oleic acid (C18:1), decreased the content of saturated very-long-chain fatty acids (VLFA) in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and controls. When confluent ALD fibroblasts were incubated with oleic acid for 5 days in lipid-free medium, which eliminates uptake of exogenous VLFA, the mean cell content of C26:0 was decreased by 33.7 +/- 10.1%. Oleic acid inhibited C26:0 synthesis in ALD fibroblasts by 58% and total fatty acid synthesis by 68 to 78%. Therefore, the elevated C26:0 levels in ALD cells may be lowered by inhibiting fatty acid biosynthesis, and inhibition of saturated VLFA synthesis by oleate may be useful in treating ALD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenoleukodystrophy / metabolism*
  • Animals
  • Cattle
  • Cell Line
  • Diffuse Cerebral Sclerosis of Schilder / metabolism*
  • Fatty Acids / metabolism*
  • Female
  • Fibroblasts / metabolism*
  • Humans
  • In Vitro Techniques
  • Male
  • Oleic Acid
  • Oleic Acids / pharmacology*
  • Skin / metabolism


  • Fatty Acids
  • Oleic Acids
  • Oleic Acid
  • hexacosanoic acid