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, 232 (4747), 232-5

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

P Rakic et al. Science.

Abstract

Synapses develop concurrently and at identical rates in different layers of the visual, somatosensory, motor, and prefrontal areas of the primate cerebral cortex. This isochronic course of synaptogenesis in anatomically and functionally diverse regions indicates that the entire cerebral cortex develops as a whole and that the establishment of cell-to-cell communication in this structure may be orchestrated by a single genetic or humoral signal. This is in contrast to the traditional view of hierarchical development of the cortical regions and provides new insight into the maturation of cortical functions.

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