From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non-Invasive Precision Medicine in Cancer Patients

Adv Sci (Weinh). 2025 Jan;12(2):e2408069. doi: 10.1002/advs.202408069. Epub 2024 Nov 13.

Abstract

With the increasing demand for precision medicine in cancer patients, radiogenomics emerges as a promising frontier. Radiogenomics is originally defined as a methodology for associating gene expression information from high-throughput technologies with imaging phenotypes. However, with advancements in medical imaging, high-throughput omics technologies, and artificial intelligence, both the concept and application of radiogenomics have significantly broadened. In this review, the history of radiogenomics is enumerated, related omics technologies, the five basic workflows and their applications across tumors, the role of AI in radiogenomics, the opportunities and challenges from tumor heterogeneity, and the applications of radiogenomics in tumor immune microenvironment. The application of radiogenomics in positron emission tomography and the role of radiogenomics in multi-omics studies is also discussed. Finally, the challenges faced by clinical transformation, along with future trends in this field is discussed.

Keywords: artificial intelligence; cancer; immune microenvironment; medical imaging; multi‐omics analysis; precision medicine; radiomics; single‐cell sequencing.

Publication types

  • Review

MeSH terms

  • Artificial Intelligence*
  • Genomics* / methods
  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / therapy
  • Precision Medicine* / methods