Mx1-ing it up-Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes

Immunity. 2024 Nov 12;57(11):2483-2486. doi: 10.1016/j.immuni.2024.10.005.

Abstract

The role of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) is well documented, but the role of interleukin (IL)-1β remains elusive. In this issue of Immunity, Caielli et al. identified an SLE monocyte population coproducing IL-1β and IFN-I and described how mitochondrial nucleic-acid-containing RBCs engage cGAS/STING, RIG-I, MDA5, and NLRP3 for unconventional IL-1β release.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Humans
  • Interferon Type I / immunology
  • Interferon Type I / metabolism
  • Interleukin-1beta* / immunology
  • Interleukin-1beta* / metabolism
  • Lupus Erythematosus, Systemic* / immunology
  • Lupus Erythematosus, Systemic* / metabolism
  • Mitochondria* / immunology
  • Mitochondria* / metabolism
  • Monocytes* / immunology
  • Monocytes* / metabolism
  • Myxovirus Resistance Proteins / genetics
  • Myxovirus Resistance Proteins / metabolism

Substances

  • Interleukin-1beta
  • Interferon Type I
  • Myxovirus Resistance Proteins