Supramarginal Resection of Glioblastoma: A Review

Neurosurg Clin N Am. 2025 Jan;36(1):83-89. doi: 10.1016/j.nec.2024.08.007. Epub 2024 Oct 16.

Abstract

This article discusses the evidence supporting the resection of glioblastoma beyond the borders of contrast-enhancing tumor. While several techniques for this have been described, including a so-called FLAIRectomy, lobectomy, or via the use of adjuncts such as fluorescence or intraoperative MRI, the optimal extent of additional resection has yet to be established. Many authors have noted a survival benefit with supramarginal resection without significant additional morbidity.

Keywords: Extent of resection; Glioblastoma; Lobectomy; Supramarginal resection; Survival.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / surgery
  • Glioblastoma* / diagnostic imaging
  • Glioblastoma* / surgery
  • Humans
  • Magnetic Resonance Imaging / methods
  • Neurosurgical Procedures* / methods
  • Treatment Outcome