cdc25+ functions as an inducer in the mitotic control of fission yeast

Cell. 1986 Apr 11;45(1):145-53. doi: 10.1016/0092-8674(86)90546-5.


In the fission yeast S. pombe the cdc25+ gene function is required to initiate mitosis. We have cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis to initiate at a reduced cell size. This shows that cdc25+ functions as a dosage-dependent inducer in mitotic control, the first such mitotic control element to be specifically identified. DNA sequencing of the cdc25+ gene has shown that it can encode a protein of MW 67,000. Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor wee1+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cell Cycle*
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes, Fungal
  • Mitosis*
  • Saccharomycetales / cytology*
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / genetics
  • Time Factors

Associated data

  • GENBANK/M13158