Understanding genetic architecture of breast cancer: how can proteome-wide association studies contribute?

Br J Cancer. 2024 Dec;131(12):1869-1870. doi: 10.1038/s41416-024-02905-2. Epub 2024 Nov 18.

Abstract

Proteome-wide association studies (PWAS) address gaps in post-transcriptional modifications that previous genome- and transcriptome-wide association studies could not capture. Zhao and colleagues conducted the first breast tissue-based PWAS and identified proteins associated with breast cancer risk, providing insights into the role of protein expression in breast cancer development.

Publication types

  • Editorial