Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection

Antimicrob Steward Healthc Epidemiol. 2024 Nov 14;4(1):e202. doi: 10.1017/ash.2024.413. eCollection 2024.

Abstract

Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult inpatients. Targeted antibiotic stewardship and judicious use of gastric acid suppressants can reduce the incidence of HA-CDI.