Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis

Jun-Qing Yue; Rui-di Tang; Wei-Jie Guan

doi:10.1016/j.xcrm.2024.101821

Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis

Cell Rep Med. 2024 Nov 19;5(11):101821. doi: 10.1016/j.xcrm.2024.101821.

Authors

Jun-Qing Yue¹, Rui-di Tang¹, Wei-Jie Guan²

Affiliations

¹ Department of Allergy and Clinical Immunology, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, Guangzhou 510120, P.R. China; Guangzhou National Laboratory, Guangzhou, Guangdong 510005, P.R. China.
² Department of Allergy and Clinical Immunology, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, Guangzhou 510120, P.R. China; Guangzhou National Laboratory, Guangzhou, Guangdong 510005, P.R. China. Electronic address: battery203@163.com.

Abstract

Stem and progenitor cell-based regenerative therapies have the potential to cure chronic respiratory diseases. Yan et al.¹ reported a clinical trial of autologous P63⁺ progenitor cell transplantation in bronchiectasis patients, highlighting autologous transplantation of P63⁺ progenitor cells as a novel candidate therapeutic option to improve pulmonary gas exchange function and quality of life.

MeSH terms

Bronchiectasis* / therapy
Humans
Lung*
Quality of Life
Stem Cell Transplantation* / methods
Stem Cells* / cytology
Transplantation, Autologous* / methods