Construction of human linkage maps: likelihood calculations for multilocus linkage analysis

Genet Epidemiol. 1986;3(1):39-52. doi: 10.1002/gepi.1370030105.


Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, 13-15*
  • Crosses, Genetic
  • Factor Analysis, Statistical
  • Female
  • Genetic Linkage*
  • Genetics, Medical*
  • Genotype
  • Humans
  • Male
  • Mathematics
  • Models, Genetic*
  • Pedigree
  • Probability
  • Recombination, Genetic