Abstract
Subcutaneous infection chambers in rabbits were infected with a strain of Staphylococcus aureus isolated from a patient with toxic shock syndrome. Estrogens (mestranol and 17-beta-estradiol) protected male rabbits and prolonged survival. Neither androgens (testosterone and dihydrotestosterone) nor progesterone affected the susceptibility of intact or ovarihysterectomized female rabbits.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Toxins*
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Enterotoxins / toxicity*
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Estradiol / pharmacology
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Female
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Gonadal Steroid Hormones / pharmacology*
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Male
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Mestranol / pharmacology
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Orchiectomy
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Ovariectomy
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Progesterone / blood
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Rabbits
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Staphylococcus aureus / pathogenicity*
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Superantigens*
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Testosterone / blood
Substances
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Bacterial Toxins
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Enterotoxins
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Gonadal Steroid Hormones
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Superantigens
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enterotoxin F, Staphylococcal
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Testosterone
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Progesterone
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Estradiol
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Mestranol