Flipping a switch on BRD4: How to control the do-it-all

Femke A H van Hout; Anniina Vihervaara

doi:10.1016/j.molcel.2024.10.039

Flipping a switch on BRD4: How to control the do-it-all

Mol Cell. 2024 Nov 21;84(22):4257-4259. doi: 10.1016/j.molcel.2024.10.039.

Authors

Femke A H van Hout¹, Anniina Vihervaara²

Affiliations

¹ Science for Life Laboratory, Stockholm, Sweden; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
² Science for Life Laboratory, Stockholm, Sweden; Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address: viher@kth.se.

PMID: 39577398
DOI: 10.1016/j.molcel.2024.10.039

Abstract

In this issue, Devaiah et al.¹ identify JNK-catalyzed phosphorylation to convert bromodomain-containing protein 4 (BRD4) from a chromatin regulator to a transcription activator.

MeSH terms

Bromodomain Containing Proteins
Cell Cycle Proteins* / genetics
Cell Cycle Proteins* / metabolism
Chromatin / genetics
Chromatin / metabolism
Humans
Nuclear Proteins / genetics
Nuclear Proteins / metabolism
Phosphorylation
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors
BRD4 protein, human
Cell Cycle Proteins
Nuclear Proteins
Chromatin
Bromodomain Containing Proteins