Diagnosis and management of mantle cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance

Allison Barraclough; Catherine Tang; Masa Lasica; Elizabeth Smyth; Melita Cirillo; Howard Mutsando; Chan Y Cheah; Matthew Ku

doi:10.1111/imj.16561

Diagnosis and management of mantle cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance

Intern Med J. 2024 Nov 23. doi: 10.1111/imj.16561. Online ahead of print.

Authors

Allison Barraclough¹, Catherine Tang^{2

3}, Masa Lasica⁴, Elizabeth Smyth⁵, Melita Cirillo^{6

7}, Howard Mutsando^{8

9}, Chan Y Cheah^{5

7}, Matthew Ku^{4

10}

Affiliations

¹ Department of Haematology, Fiona Stanley Hospital, Perth, Western Australia, Australia.
² Department of Haematology, Gosford Hospital, Gosford, New South Wales, Australia.
³ School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia.
⁴ Department of Haematology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
⁵ Department of Haematology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
⁶ Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia.
⁷ Medical School, University of Western Australia, Perth, Western Australia, Australia.
⁸ Cancer Services, Toowoomba Hospital, Toowoomba, Queensland, Australia.
⁹ Toowoomba Rural Clinical School, University of Queensland, Toowoomba, Queensland, Australia.
¹⁰ University of Melbourne, Melbourne, Victoria, Australia.

PMID: 39578957
DOI: 10.1111/imj.16561

Abstract

Mantle cell lymphoma (MCL) is a clinically heterogeneous B-cell neoplasm with unique clinicopathological features, accounting for 5% of all non-Hodgkin lymphoma. Although for many chemoimmunotherapy can lead to durable remissions, those with poor baseline prognostic factors, namely blastoid morphology, TP53 aberrancy and Ki67 >30%, will have less durable responses to conventional therapies. With this in mind, clinical trials have focused on novel targeted therapies to improve outcomes. This review details the recent advances in the understanding of MCL biology and outlines the recommended diagnostic strategies and evidence-based approaches to treatment.

Keywords: disease management; lymphoma; mantle cell lymphoma; non‐Hodgkin lymphoma; practice guideline.