SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu

Trends Immunol. 2024 Dec;45(12):925-927. doi: 10.1016/j.it.2024.11.002. Epub 2024 Nov 22.

Abstract

Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COVID-19* / immunology
  • COVID-19* / virology
  • Epigenesis, Genetic / immunology
  • Humans
  • Immunity, Innate
  • Influenza A virus / immunology
  • Influenza A virus / physiology
  • Macrophages, Alveolar* / immunology
  • Macrophages, Alveolar* / virology
  • Mice
  • Orthomyxoviridae Infections* / immunology
  • Orthomyxoviridae Infections* / virology
  • SARS-CoV-2* / immunology
  • SARS-CoV-2* / physiology