Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells

J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.


We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.

MeSH terms

  • Animals
  • Cell Survival
  • Diabetes Mellitus, Experimental / prevention & control*
  • Major Histocompatibility Complex*
  • Rats
  • Rats, Inbred BUF
  • Rats, Inbred Strains
  • Spleen / cytology*
  • Spleen / transplantation
  • Time Factors