Stability of cefuroxime sodium in some aqueous buffered solutions and intravenous admixtures

J Clin Hosp Pharm. 1986 Feb;11(1):47-54. doi: 10.1111/j.1365-2710.1986.tb00827.x.

Abstract

Cefuroxime sodium (Zinacef) is a new semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration which is stable to most of the beta-lactamases. The stability of cefuroxime sodium in aqueous solutions, with or without phosphate buffer, and in 5% dextrose and 0.9% sodium chloride injections was studied using a stability-indicating high-pressure liquid chromatographic method developed in our laboratory. The optimum pH range of stability was determined to be approximately 4.5-7.3. Both buffered and unbuffered solutions followed first-order decomposition. In 5% dextrose and 0.9% sodium chloride injections, cefuroxime was stable for 1 day (more than 90% potent) at 25 degrees C and for at least 30 days at 5 degrees C. At -10 degrees C, there was negligible decomposition after 30 days. The pH values of the solutions stored at 5 degrees C and -10 degrees C remained in the maximum stability range and the solutions were clear even after 30 days of storage. Thawing the frozen solutions in a microwave oven adversely affected the stability.

MeSH terms

  • Buffers
  • Cefuroxime / administration & dosage
  • Cefuroxime / analysis*
  • Cephalosporins / analysis*
  • Chemistry, Pharmaceutical
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Hydrogen-Ion Concentration
  • Injections, Intravenous
  • Temperature
  • Time Factors

Substances

  • Buffers
  • Cephalosporins
  • Cefuroxime