Treatment of primary and secondary syphilis: serologic response

J Am Acad Dermatol. 1986 Mar;14(3):487-91. doi: 10.1016/s0190-9622(86)70063-7.


Eighty-eight patients with their first attack of primary syphilis and 101 patients with secondary syphilis were treated with penicillin G benzathine, 2.4 million units intramuscularly each week for 2 consecutive weeks, for a total of 4.8 million units. The serum of all patients with primary syphilis became negative within 1 year and of those in the secondary stage, within 2 years. This report confirms three previously published articles on the serologic response to treatment in a grand total of 588 patients with primary syphilis and 623 patients in the secondary stage.

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Penicillin G / therapeutic use*
  • Penicillin G Benzathine / therapeutic use*
  • Syphilis / drug therapy*
  • Syphilis Serodiagnosis


  • Penicillin G
  • Penicillin G Benzathine