DNA bending at adenine . thymine tracts

Nature. 1986 Apr 10-16;320(6062):501-6. doi: 10.1038/320501a0.

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA . dT which are at least 4 base pairs long; the A . T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A . T tract and adjacent B-DNA, with a larger angle at the 3' than at the 5' end of the A tract.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenine*
  • Base Sequence
  • DNA / analysis*
  • Electrophoresis, Polyacrylamide Gel
  • Nucleic Acid Conformation*
  • Poly dA-dT
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Temperature
  • Thymine*

Substances

  • Poly dA-dT
  • DNA
  • Adenine
  • Thymine