Toxicity of intravitreal interferon

Ophthalmic Surg. 1986 Feb;17(2):103-5.

Abstract

We evaluated the toxicity of injecting human fibroblast interferon intravitreally in rabbit eyes. A single intravitreal injection of 166,660 units/0.1 ml was nontoxic to ocular structures, as demonstrated by electroretinographic and histologic examination.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electroretinography
  • Humans
  • Injections
  • Interferon Type I / administration & dosage
  • Interferon Type I / adverse effects*
  • Rabbits
  • Vitreous Body / drug effects*

Substances

  • Interferon Type I