Circulating mannose-binding lectin in diabetic patients and risk of vascular complications: a systematic review and meta-analysis

Mohammad Sedghi; Ali Ranjbaran; Mahtab Forouhi; Mahdi Nejatianfar; Nazanin Azmi-Naei; Parian Pourmoafi Esfahani; Mahdi Tavakoli; Fatemeh Sadat Hashemi Javaheri; Nazanin Shakibi; Elham Mirzaee; Akram Mirzaee; Hannaneh Nejati; Mansoureh Makarem; Tahereh Parishan Kordiani; Gita Pourshahikhaneh; Rasoul Shavaleh; Kazem Rahmani; Molood Foogerdi

doi:10.1007/s40200-024-01478-4

Circulating mannose-binding lectin in diabetic patients and risk of vascular complications: a systematic review and meta-analysis

J Diabetes Metab Disord. 2024 Aug 5;23(2):2131-2142. doi: 10.1007/s40200-024-01478-4. eCollection 2024 Dec.

Authors

Mohammad Sedghi¹, Ali Ranjbaran², Mahtab Forouhi³, Mahdi Nejatianfar⁴, Nazanin Azmi-Naei⁵, Parian Pourmoafi Esfahani⁶, Mahdi Tavakoli⁷, Fatemeh Sadat Hashemi Javaheri⁸, Nazanin Shakibi⁹, Elham Mirzaee¹⁰, Akram Mirzaee¹⁰, Hannaneh Nejati⁴, Mansoureh Makarem¹¹, Tahereh Parishan Kordiani¹², Gita Pourshahikhaneh¹², Rasoul Shavaleh¹³, Kazem Rahmani¹³, Molood Foogerdi¹⁴

Affiliations

¹ Molecular and Cellular biology, Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahr-e- Rey Branch, Islamic Azad University, Tehran, Iran.
² Faculty of pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
³ School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Research and Development, Organic Chemistry Hila Pharmaceutical Co, Mashhad, Iran.
⁵ Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran.
⁶ School of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁷ Shahrekord University of Medical Sciences, Shahrekord, Iran.
⁸ Department of Clinical Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
⁹ Arak University of Medical Sciences, Arak, Iran.
¹⁰ Chemistry Department of Islamic Azad University, Mashhad, Iran.
¹¹ Health Vice-Chancellor, Torbat-e Jam Faculty of Medical Sciences, Torbat-e Jam, Iran.
¹² Non-communicable disease center, Torbat-e Jam University of Medical Sciences, Torbat-e Jam, Iran.
¹³ Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
¹⁴ Department of Emergency Medicine, Faculty of Medicine, Birgand University of Medical Sciences, Birjand, Iran.

PMID: 39610514
PMCID: PMC11599526 (available on 2025-08-05)
DOI: 10.1007/s40200-024-01478-4

Abstract

Objectives: Recent studies have confirmed the involvement of mannose-binding lectin (MBL) in the pathogenesis of vascular complications in individuals with diabetes. Due to the discrepancy between the results of studies, a meta-analysis was conducted to evaluate MBL levels in patients with diabetes and its vascular complications.

Methods: We reviewed all observational studies published in PubMed/Medline, Scopus, EMBASE, and Web of Science Core Collection databases to identify relevant studies up to 1 April 2024. To account for describing heterogeneity among the studies, I² and χ² statistics were utilized. Also, a random-effects model was employed to combine the studies. The Newcastle Ottawa Scale (NOS) checklist was applied for quality assessment of each study.

Results: Twenty-eight papers were encompassed in this meta-analysis. The mean difference in MBL levels between patients with diabetic nephropathy and diabetic retinopathy differed significantly compared with the healthy control group and the diabetic group without vascular complications (P-value < 0.05). Moreover, the pooled results revealed a significant relationship between MBL levels and the incidence of vascular complications (pooled HR = 1.44, 95% CI: 1.07-1.95, P-value < 0.05) and disease-related mortality (pooled HR = 1.52, 95% CI: 1.07-2.16, P-value < 0.05) among diabetic patients. Also, there was a direct association between incidence of nephropathy in diabetics and higher levels of MBL (pooled HR = 2.16, 95% CI: 1.52-3.08, P-value < 0.05).

Conclusion: Diabetic patients with elevated MBL levels are potentially at increased risk of vascular complications such as nephropathy and retinopathy. Therefore, by determining MBL status in diabetic patients, it is possible to predict the progress and possible consequences of the disease.

Keywords: Complement system; Diabetes; Inflammation; MBL; Vascular complications.

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