Recurrence and influencing factors of hepatitis B surface antigen seroclearance induced by peginterferon alpha-based regimens

World J Gastroenterol. 2024 Nov 28;30(44):4725-4737. doi: 10.3748/wjg.v30.i44.4725.

Abstract

Background: The long-term stability of hepatitis B surface antigen (HBsAg) seroclearance following peginterferon alpha (peg-IFN-α)-based therapy has not been extensively studied, leaving the full potential and limitations of this strategy unclear.

Aim: To assess HBsAg recurrence after seroclearance achieved by peg-IFN-α regimens.

Methods: This prospective, multicenter, observational study was conducted from November 2015 to June 2021 at three Chinese hospitals: The Second Affiliated Hospital of Xi'an Jiaotong University, Ankang Central Hospital, and The Affiliated Hospital of Yan'an University. Participants who achieved HBsAg seroclearance following peg-IFN-α-based treatments were monitored every 4-12 weeks post-treatment for hepatitis B virus (HBV) markers, HBV DNA, and liver function. The primary outcome was HBV recurrence, defined as the reemergence of HBsAg, HBV DNA, or both, at least twice within 4-8 weeks of follow-up.

Results: In total, 121 patients who achieved HBsAg seroclearance were enrolled. After a median follow-up of 84.0 (48.0, 132.0) weeks, four subjects were lost to follow-up. HBsAg recurrence was detected in 16 patients. The cumulative HBsAg recurrence rate in the intention-to-treat population was 15.2%. Multivariate logistic regression analysis demonstrated that consolidation time < 12 weeks [odds ratio (OR) = 28.044, 95%CI: 4.525-173.791] and hepatitis B surface antibody disappearance during follow-up (OR = 46.445, 95%CI: 2.571-838.957) were strong predictors of HBsAg recurrence. HBV DNA positivity and decompensation of liver cirrhosis and hepatocellular carcinoma were not observed.

Conclusion: HBsAg seroclearance following peg-IFN-α treatment was durable over 84 weeks of follow-up with a cumulative recurrence rate of 15.2%.

Keywords: Chronic hepatitis B; Clinical cure; Hepatitis B surface antigen recurrence; Hepatitis B surface antigen seroclearance; Peginterferon alpha.

Publication types

  • Observational Study
  • Multicenter Study
  • Review

MeSH terms

  • Adult
  • Antiviral Agents* / adverse effects
  • Antiviral Agents* / therapeutic use
  • China / epidemiology
  • DNA, Viral* / blood
  • Female
  • Follow-Up Studies
  • Hepatitis B Surface Antigens* / blood
  • Hepatitis B Surface Antigens* / immunology
  • Hepatitis B virus* / drug effects
  • Hepatitis B virus* / immunology
  • Hepatitis B virus* / isolation & purification
  • Hepatitis B, Chronic* / blood
  • Hepatitis B, Chronic* / diagnosis
  • Hepatitis B, Chronic* / drug therapy
  • Hepatitis B, Chronic* / immunology
  • Hepatitis B, Chronic* / virology
  • Humans
  • Interferon-alpha* / therapeutic use
  • Male
  • Middle Aged
  • Polyethylene Glycols* / adverse effects
  • Polyethylene Glycols* / therapeutic use
  • Prospective Studies
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / therapeutic use
  • Recurrence*
  • Treatment Outcome
  • Viral Load

Substances

  • Hepatitis B Surface Antigens
  • Interferon-alpha
  • Antiviral Agents
  • DNA, Viral
  • Polyethylene Glycols
  • Recombinant Proteins