Oscillatory Traveling Waves Provide Evidence for Predictive Coding Abnormalities in Schizophrenia

Abstract

Background: The computational mechanisms underlying psychiatric disorders are hotly debated. One hypothesis, grounded in the Bayesian predictive coding framework, proposes that patients with schizophrenia have abnormalities in encoding prior beliefs about the environment, resulting in abnormal sensory inference, which can explain core aspects of the psychopathology, such as some of its symptoms.

Methods: Here, we tested this hypothesis by identifying oscillatory traveling waves as neural signatures of predictive coding. We analyzed an electroencephalography dataset comprising 146 patients with schizophrenia and 96 age-matched healthy control participants during resting states and a visual backward masking task.

Results: We found that patients with schizophrenia had stronger top-down alpha-band traveling waves compared with healthy control participants during resting state, supposedly reflecting overly precise priors at higher levels of the predictive processing hierarchy. We also found stronger bottom-up alpha-band waves in patients with schizophrenia during a visual task, consistent with the notion of enhanced signaling of sensory precision errors.

Conclusions: Our results yield a novel spatial-based characterization of oscillatory dynamics in schizophrenia, considering brain rhythms as traveling waves and providing a unique framework to study the different components involved in a predictive coding scheme. All together, our findings significantly advance our understanding of the mechanisms involved in fundamental pathophysiological aspects of schizophrenia, promoting a more comprehensive and hypothesis-driven approach to psychiatric disorders.

Keywords: Predictive coding; Psychiatry; Resting-state; Schizophrenia; Traveling waves.