Updated Findings on the Efficacy of Combined Subanesthetic Ketamine Infusion and Cervical Sympathetic Blockade as a Symptomatic Treatment of PTSD/TBI in a Special Forces Patient with a 2-year Follow-up: A Case Report

J Spec Oper Med. 2025 Apr 30;24(4):102-104. doi: 10.55460/2QC5-PHPF.

Abstract

Posttraumatic stress disorder (PTSD)/blast traumatic brain injury (bTBI) in a Special Operations Forces (SOF) cohort has been shown to be successfully treated using a cervical sympathetic blockade (CSB)/ketamine infusion (KI) combination, termed the SOF method. In a prior case report, the patient was followed for 1 year. This report followed the same patient for a total of 720 days and found prolonged and sustained benefits with respect to PTSD and bTBI symptoms with further application of the SOF method.

Keywords: PTSD; SOF; TBI; bTBI; cervical sympathetic blockade; ketamine infusion.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthetics, Dissociative* / administration & dosage
  • Anesthetics, Dissociative* / therapeutic use
  • Autonomic Nerve Block* / methods
  • Brain Injuries, Traumatic* / complications
  • Brain Injuries, Traumatic* / drug therapy
  • Brain Injuries, Traumatic* / therapy
  • Humans
  • Ketamine* / administration & dosage
  • Ketamine* / therapeutic use
  • Male
  • Military Personnel* / psychology
  • Stress Disorders, Post-Traumatic* / drug therapy
  • Stress Disorders, Post-Traumatic* / therapy

Substances

  • Ketamine
  • Anesthetics, Dissociative