The prophylaxis of purulent omphalitis is an urgent problem of epidemiology and obstetrics. A high morbidity rate in omphalitis and umbilical sepsis has been noted after the treatment of the umbilical bed by commonly used methods. As revealed in our investigations, two new treatment methods have proved to be highly effective for this purpose: treatment with the preparation Narine-phi containing the metabolic products of lactobacterial strain 317/402 Narine and treatment with the film-forming preparation Lifuzol. Both methods have made it possible to achieve a significant decrease in the contamination of the umbilical bed of newborns by hospital microorganisms and in morbidity rate in purulent omphalitis as compared with those in the control group.