Influence of exfoliation syndrome on prognosis in ocular hypertension greater than or equal to 25 mm. A long-term follow-up

Acta Ophthalmol (Copenh). 1986 Feb;64(1):39-44. doi: 10.1111/j.1755-3768.1986.tb06869.x.


Data on 144 patients who in 1969-1973 were found to have ocular hypertension greater than or equal to 25 mmHg without glaucomatous damage were collected retrospectively. Intraocular pressure-lowering treatment was prescribed with few exceptions. Thirteen out of 37 patients (35%) with exfoliation syndrome developed glaucomatous damage during the follow-up periods ranging from 5 to 14 years (mean 9.4 years). The corresponding result for patients without exfoliation syndrome was 20 out of 111 subjects (18%, mean follow-up 11.7 years, range 5-15 years). Low average intraocular pressure during the follow-up seemed to prevent the eyes from developing glaucomatous damage. This was especially evident for eyes with the exfoliation syndrome. The long-term effect of medical therapy on the pressure level of hypertensive eyes was often negligible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Eye Diseases / complications*
  • Female
  • Follow-Up Studies
  • Glaucoma / etiology*
  • Humans
  • Lens, Crystalline / pathology
  • Male
  • Middle Aged
  • Ocular Hypertension / complications
  • Ocular Hypertension / diagnosis*
  • Ocular Hypertension / drug therapy
  • Prognosis
  • Retrospective Studies
  • Syndrome
  • Visual Fields