Severe liver injury due to phenelzine with unique hepatic deposition of extracellular material

Am J Med. 1986 Apr;80(4):689-92. doi: 10.1016/0002-9343(86)90826-0.


Severe acute and chronic hepatic damage occurred in a white man who had taken phenelzine sulfate (Nardil) 45 mg daily for 70 days. Liver biopsy showed a mixed hepatitic and cholestatic pattern with extracellular deposition of a unique homogeneous collagenous substance. Portal cirrhosis developed and has persisted. The patient was found to have a "rapid acetylator phenotype" and high rate of metabolism of antipyrine. These innate factors may have predisposed to hepatic injury due to phenelzine.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chemical and Drug Induced Liver Injury / pathology*
  • Extracellular Space
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged
  • Phenelzine / adverse effects*


  • Phenelzine