Association between PRNCR1, PAX8AS1, MEG3, and PTENP1 gene polymorphisms and breast cancer risk

Per Med. 2024;21(6):373-383. doi: 10.1080/17410541.2024.2435800. Epub 2024 Dec 5.

Abstract

Aim: In this study, we examined the polymorphisms of PRNCR1 (rs13252298, rs1456315), PAX8-AS1 (rs4848320) MEG3 (rs7158663), PTENP1 (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.

Method: The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.

Results & conclusion: The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC. The CT and TT genotype and Dominant and T allele of rs4848320 polymorphism is also a risk factor in the study population. The genotype AA, dominant, recessive and A allele of rs7158663 polymorphism and also CC genotype of rs7853346 polymorphism increase the risk of BC.

Keywords: Breast cancer; MEG3; PAX8AS1; PRNCR1; PTENP1; polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Breast Neoplasms* / genetics
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease* / genetics
  • Genotype*
  • Humans
  • Iran
  • Middle Aged
  • Polymorphism, Single Nucleotide* / genetics
  • RNA, Long Noncoding* / genetics
  • Risk Factors

Substances

  • MEG3 non-coding RNA, human
  • RNA, Long Noncoding