Progressive multifocal leukoencephalopathy complicating systemic lupus erythematosus

Arthritis Rheum. 1986 Mar;29(3):337-43. doi: 10.1002/art.1780290305.


Two patients with systemic lupus erythematosus who developed progressive multifocal leukoencephalopathy (PML) are described. Although the time of PML onset could not be determined with certainty, it probably developed after steroid-induced immunosuppression. However, high-dose corticosteroids appeared to produce transient amelioration in the neurologic disorder. We suggest that PML is an important addition to the list of conditions to be considered in the differential diagnosis when a patient with systemic lupus erythematosus develops neurologic abnormalities.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology
  • Brain / ultrastructure
  • Diagnosis, Differential
  • Female
  • Humans
  • Leukoencephalopathy, Progressive Multifocal / diagnosis
  • Leukoencephalopathy, Progressive Multifocal / etiology*
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / diagnosis
  • Microscopy, Electron
  • Middle Aged